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Nov 15, 2015; East Rutherford, NJ, USA; New England Patriots head coach Bill Belichick during the game against the New York Giants at MetLife Stadium. Mandatory Credit: Robert Deutsch-USA TODAY Sports
Home » Blog » NFL Week 2 2022: 5 teams on upset alert this Sunday

NFL Week 2 2022: 5 teams on upset alert this Sunday

With the NFL Week 2 schedule about to kick into high gear, we look at five teams on upset alert this weekend.

5. San Francisco 49ers (-9) vs. Seattle Seahawks

Not often does a team laying these many points at home end up on upset alert. However, the 49ers are 0-1 and don’t know what quality of quarterback they have in Trey Lance, who struggled badly against the Chicago Bears in Week 1. If Lance doesn’t play a solid game, covering nine points seems daunting. Perhaps beating a division rival will prove to be as well. And if that plays out, does San Francisco turn to Jimmy Garoppolo in Week 3?


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4. Las Vegas Raiders (-5.5) vs. Arizona Cardinals

This is a fascinating game. The Raiders and Cardinals both have playoff aspirations, and both are 0-1. History says whoever loses this game is in. serious trouble as far as the postseason is concerned. The Raiders are at home but are also trying to defend quarterback Kyler Murray, who can beat them with his arm and legs. If the Las Vegas pass rush doesn’t get home, it could be a very close game into the fourth quarter, with Arizona having a chance to win late.

3. Indianapolis Colts (-3) at Jacksonville Jaguars

The Colts are coming into Jacksonville wounded. Wide receivers Alec Pierce and Michael Pittman have both been ruled. out, while All-Pro linebacker Shaquille Leonard is also missing another game while he recovers from back surgery. Without all theses pieces — along with defensive tackle DeForest Buckner and corner Kenny Moore being questionable — it’s reasonable to think the Jaguars not only cover but win outright in a game Indy might have trouble with from the start.


Read: Cooper Rush ‘Can’t Wait’ To Help Cowboys Bounce Back In Week 2


2. Tampa Bay Buccaneers (-2.5) at New Orleans Saints

The Buccaneers are favored going into the Superdome, and that’s somewhat interesting. Tom Brady is 0-4 in the regular season against the Saints during the regular season since joining Tampa Bay, and the Bucs are beat up. They’re down three starting offensive linemen from when training camp began, and receiver Chris Godwin won’t play while Mike Evans is questionable. New Orleans has a talented roster and with a vocal crowd behind it, could absolutely pull the upset.

1. New England Patriots (-2.5) at Pittsburgh Steelers

Why are the Patriots favored? They are on the road, looked awful in Week 1 against the Miami Dolphins, and face the Steelers who even without T.J. Watt are loaded defensively. Pittsburgh has a chance to not only win outright, but win convincingly.

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